Wear long sleeves, pants, closed shoes, thick gloves, and even a mask when removing poison ivy and poison oak.
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Wash it away. Do not wipe with water—urushiol is an oil, so it does not dissolve in water. Rinse the affected skin with isopropyl (rubbing) alcohol, then with cold water. Don't wipe. Wiping spreads the oil.
Over-the-counter topicals such as Tecnu, Ivy Complete, Zanfel, or Burt's Bees Poison Ivy Soap and Res-Q Ointment also remove the oil and relieve itching. Without treatment, the infected area will blister within a few hours to three days. The fluid in the blisters will not spread the rash, but any clothing that has come into contact with the oil will. Oral antihistamines can help, if needed.